Evolution of gene network activity by tuning the strength of negative-feedback regulation
نویسندگان
چکیده
منابع مشابه
Evolution of gene network activity by tuning the strength of negative-feedback regulation.
Despite the examples of protein evolution via mutations in coding sequences, we have very limited understanding on gene network evolution via changes in cis-regulatory elements. Using the galactose network as a model, here we show how the regulatory promoters of the network contribute to the evolved network activity between two yeast species. In Saccharomyces cerevisiae, we combinatorially repl...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms7226